The origin of SARS-CoV-2, revisited

Since early in the pandemic, scientists have overwhelmingly concluded that the evidence makes a natural origin for SARS-CoV-2, the coronavirus that causes COVID-19, a far more likely explanation for the pandemic than a laboratory origin. Over the last three weeks or so, however, there has been considerable chatter about the “lab leak” hypothesis, and President Biden even ordered US intelligence agencies to…

Source: The origin of SARS-CoV-2, revisited

Public oppose bishops in the Lords by more than three to one – new poll

A new survey has shown that the British public is against the House of Lords continuing to have places for Church of England bishops by more than three to one. The YouGov poll found that 53% of adults favour removing the bishops, with only 16% favouring keeping them. The result was consistent across supporters of […]

Source: Public oppose bishops in the Lords by more than three to one – new poll

Vaccine Effectiveness

Invasive apps – The pCloud Blog

Which apps are sharing your details with others? Our report finds out, looking at the information they collect, store and share for their own gain.

 

Source: Invasive apps – The pCloud Blog

Barefoot at the Keyboard

Like many people, I have spent extra hours surfing the web during the lockdown. During one excursion, I stumbled across the German rock group, AnnenMayKantereit (AMK for short). They hail from Cologne; a city for which I have fond memories, having worked on a project there for a year or so some time back.

AMK sing mainly in German, but there are some great covers to be found on YouTube. You can also find their songs on Apple Music. The band’s lead singer is Henning May who has a marvellous, gravelly voice as evidenced in this video.

I don’t speak German. The little tourist competence I acquired while working in Cologne has pretty much evaporated. I can remember, “Noch eins Kölsch, bitte”. With the aid of Google Translate and Wiktionary, I offer this English translation.

And I’m sitting again
Barefoot at the piano
I dream love songs
And sing about you

You and I, we were strange
Not for me, for those who were bothered
If you could hear us at night
I sat around lonely with you and in silence
I remember best lying lonely together, every morning
Then with you, you naked in bed and I barefoot at the piano

And I’m sitting again
Barefoot at the piano
I dream love songs
And sing about you

You and me, it didn’t work that way
You wanted to know everything and that drove me away
Actually you, you didn’t stay longer with me
So to live I prefer to sit barefoot at the piano

And I’m sitting again
Barefoot at the piano
I dream love songs
And sing about you
You and me, that was not enough
I dream about you

And I’m sitting again
Barefoot at the piano
And dream about you
I dream about you
I dream about you

A “not antivaccine” antivax pediatrician asks how we will know a COVID-19 vaccine is safe and effective

Dr. Liz Mumper is associated with Robert F. Kennedy, Jr.’s antivax organization Children’s Health Defense. She recently gave a presentation asking: How will we know that a COVID vaccine is safe? It’s a presentation that provides an excellent example of how to identify if someone is antivaccine.

Source: A “not antivaccine” antivax pediatrician asks how we will know a COVID-19 vaccine is safe and effective

The American Abyss

America will not survive the big lie just because a liar is separated from power. It will need a thoughtful repluralization of media and a commitment to facts as a public good. The racism structured into every aspect of the coup attempt is a call to heed our own history. Serious attention to the past helps us to see risks but also suggests future possibility. We cannot be a democratic republic if we tell lies about race, big or small. Democracy is not about minimizing the vote nor ignoring it, neither a matter of gaming nor of breaking a system, but of accepting the equality of others, heeding their voices and counting their votes.

Denial Is the Heartbeat of America

When have Americans been willing to admit who we are?

We must stop the heartbeat of denial and revive America to the thumping beat of truth. The carnage has no chance of stopping until the denial stops. This is not who we are must become, in the aftermath of the attack on the U.S. Capitol: This is precisely who we are. And we are ashamed. And we are aggrieved at what we’ve done, at how we let this happen. But we will change. We will hold the perpetrators accountable. We will change policy and practices. We will radically root out this problem. It will be painful. But without pain there is no healing.

And in the end, what will make America true is the willingness of the American people to stare at their national face for the first time, to open the book of their history for the first time, and see themselves for themselves—all the political viciousness, all the political beauty—and finally right the wrongs, or spend the rest of the life of America trying.

This can be who we are.

Source: Denial Is the Heartbeat of America

How can we fight bad information about health?

Full Fact’s Researcher Dr. Dora-Olivia Vicol looks at health misinformation, and how fact checkers and the general public can stand up to crises, conspiracies, and inaccurate everyday health advice.

Source: How can we fight bad information about health?

Download PDF of full report

Coronavirus: why we’re using llamas to help fight the pandemic

shutterstock.

Gary Stephens, University of Reading

The search is on for effective treatments to combat the unprecedented COVID-19 pandemic. Given the lengthy development process for vaccines, one major immediate priority is the development of selective antibodies that can neutralise the SARS-CoV-2 virus responsible for COVID-19. And a particularly exciting new advance is the recent development of “nanobody” technology.

Nanobodies are smaller, more stable types of antibody taken from the immune systems of camelid species – such as llamas, alpacas and camels – that could be more effective at fighting disease. A recent report confirmed that llama nanobodies could neutralise the SARS and MERS viruses and could also be engineered to fight SARS-CoV-2.

Since 2015, the University of Reading has collaborated with several academic and industry partners to generate specialised nanobodies from llamas. We currently keep a herd of 15 llamas at the university, including a recent unexpected arrival in the form of a cria (baby llama), whose mother surprised everyone when her pregnancy was discovered.

The timing of the birth coincided with the leadership contest of the UK Conservative Party in July 2019 and an online poll was launched to name the cria “Boris” or “Jeremy” after the candidates Johnson and Hunt. Jeremy won on this occasion and so baby Jeremy has joined the effort to discover new nanobodies, along with older llamas such as Fifi, who is leading our search for COVID nanobodies.

Fifi the llama is among those providing blood samples for COVID-19 research. University of Reading, Author provided

Our aim is to generate llama nanobodies that bind to proteins in the SARS-CoV-2 virus. These proteins include the “spike” glycoprotein that enables the virus to enter human cells, so these nanobodies could help neutralise it.

We inject the llamas with isolated proteins from the virus and then collect samples of their blood containing nanobodies produced in response by the immune system. Because we are only injecting individual proteins not the entire virus, the animals are not infected. We work with a range of partners, including those at the University of Oxford, Rosalind Franklin Institute and Francis Crick Institute, who extract and test the nanobodies and then reproduce them at a larger scale.

This strategy was recently given a boost by the report that researchers in the US and Belgium had generated llama nanobodies that bind to the spike protein of the SARS-CoV-1 and MERS-CoV coronaviruses behind the SARS and MERS diseases, respectively. What was particularly encouraging was that researchers also demonstrated that engineered nanobodies could neutralise these viruses, but also SARS-CoV-2, in the lab.

They also noted that a conventional antibody (called CR3022), another one that is good at binding to the SARS-CoV-2 spike protein, was unable to neutralise the virus in the same way that the llama nanobody was able to.

Now the hope is that similar llama nanobodies directed specifically against the SARS-CoV-2 version of the spike protein – and potentially against an additional range of viral proteins – may hold the key to combating COVID-19. The next step would be to trial the nanobodies in small animals and then non-human primates.

If this is successful, the authors of the report estimate the first tests of their nanobodies in humans could occur in around one year’s time. Due to their small size, nanobodies could potentially be converted into a fine spray (nebulised) and inhaled – ideal for a respiratory disease such as COVID-19.

Tiny defenders

Llama nanobodies have several potential advantages over conventional antibodies. Each type of antibody is a large compound consisting of “light” and “heavy” chains of molecules, some parts of which are always the same and some parts of which vary between individual antibodies. By contrast, nanobodies consist only of the variable part of heavy chain (VHH).

The VHH region is the “business” part of the molecule, responsible for binding to whatever invader it was created to fight. This means nanobodies can have similar neutralising function to their larger antibody relatives without the extra baggage that other chains add. As a result, nanobodies may be able to access targets that conventional antibodies cannot reach and better avoid detection by the virus. Nanobodies are also more stable in response to heat or chemical attack.

Nanobodies can be produced, stored and even stockpiled as needed. Their properties mean they can be used to bind to and stabilise protein molecules, such as those that may cause disease in the body. The first nanobody drug, capacizumab, was approved in 2018 and binds to a protein present in human blood to prevent a rare blood clotting disease.

There are also other ways in which a nanobody used against a coronavirus protein could be useful. If a nanobody can bind to a viral protein then this could allow gathering of detailed information about the structure of the protein and how it is presented within the virus.

This could help in the development of new drugs that may treat the infection. Llama nanobodies might also be used to develop much-needed, efficient and rapid diagnostic tests.

Because our work involves animals, it’s important to note that the University of Reading is a signatory to the Concordat on Openness on Animal Research in the UK. In 2019, the university won an Openness Award for its llama research social media campaign. The university is also committed to the principles of “the 3Rs”, working to replace, reduce and refine procedures on animals.

Gary Stephens, Professor of Pharmacology, University of Reading

This article is republished from The Conversation under a Creative Commons license. Read the original article.

https://oddrops.blog/2020/05/26/8523/